Cancer/Leishmania treatment with LupArte2.0 ® capsules/tablets (Active ingredient-optimized mixture of Artemisia annua plant leaves and Artennua, Lupovet Ltd) for cats/dogs (in line with the artemisinin-based combination therapy (ACT) of the WHO):
1. Preparation phase
Cancer: Anti-inflammatory treatment (with Meloxicam as anti-inflammatory suspension); surgical removal of the tumor (no matter if metastasis has occurred or not), if possible; initial serum iron measurement
Leishmaniosis: initial serum iron measurement
2.Treatment phase
with LupArte 2.0 ®
- Determination of the serum iron (normal range between 140 – 170 µg/dl), often too low in case of a malignant tumor
- At the same time iron must be given either:A) Orally in the form of LupoVet LuCefer Iron Powder
High-dose oral iron source with 10% absorption-promoting vitamin C
Dosage: administer up to 2 x 1 level measuring spoon per 10 kg live weight per day, ideally mixed with the feed in 1 tablespoon of wet food; Measuring spoon content: level = 4.5 g, heaped = 7.5 g
B) Or per injection of Ursoferran® (100mg/ml); dosage: 100 mg/10 kg weight initially two times a week (this is cheaper and more effective)
The iron application must be continued for the entire treatment period and adjusted accordingly to reach the (high) level of 250 + 30 µg/dl.
- From the fourth day onward, the animal must be treated with LupArte 2.0® capsules/tablets three times daily. The dosage is about 1400 mg/m² body surface and per day (see conversion table below). It is given in three partial dosages approximately every 8 hours if possible. The capsules shall be given 1 – 2 hours before feeding and – if possible – without meat in a little piece of Gouda cheese. Giving four dosages a day may be more helpful than giving three dosages a day since we know that this drug has a relatively short half-life period.
During treatment the serum iron must be continuously controlled and adjusted if necessary.
Conversion table
| weight [kg] | surface of the body [m²] |
| 0,5 | 0,06 |
| 1 | 0,1 |
| 2 | 0,16 |
| 5 | 0,29 |
| 10 | 0,46 |
| 15 | 0,61 |
| 20 | 0,74 |
| 30 | 0,97 |
| 40 | 1,17 |
| 50 | 1,36 |
| 60 | 1,63 |
| 70 | 1,7 |
3. Continuation:
Regular iron serum check:
Target: 250 + 30 µg/dl.; adjusted iron substitution (oral/parenteral); life-long treatment with LupArte2.0® with the standard dosage.
Link:
https://www.who.int/malaria/areas/treatment/overview/en/